A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance
Liaki V, Barrambana S, Kostopoulou M, Lechuga CG, Zamorano-Dominguez E, Acosta D, Morales-Cacho L, Álvarez-Díaz R, Sun P, Rosas-Perez B, Barrero R, Jiménez-Parrado S, López-García A, San Roman M, López-Gil JC, Drosten M, Sainz B Jr, Musteanu M, Caleiras E, Dusetti N, Poli V, Sánchez-Bueno F, Guerra C, Barbacid M. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2523039122. doi: 10.1073/pnas.2523039122. Epub 2025 Dec 2. PMID: 41329731
An audit of the PeptideAtlas database uncovers evidence for repurposed pseudogenes and co-opted retroviral ORFs
Rodriguez JM, Maquedano M, Cerdán-Vélez D, Laguillo-Gómez A, Calvo E, Abascal F, Vázquez J, Tress ML. BMC Genomics. 2025 Nov 21;26(1):1087. doi: 10.1186/s12864-025-12238-w. PMID: 41272456
Co-clinical trial targeting ER, FGFR and CDK4/6 in resistant hormone-positive breast cancer with FGFR alterations
Martinez-Jañez N, García-Saenz JÁ, Pernas S, Bermejo B, Morales S, Guerra J, Silva J, Manso L, Ciruelos E, Tolosa P, Sánchez-Bayona R, Alva M, Calabuig-Fariñas S, Gallach S, Muinelo-Romay L, Piñeiro-Yáñez E, Caleiras E, Bueno MJ, Mouron S, Quintela-Fandino M. NPJ Precis Oncol. 2025 Nov 7;9(1):343. doi: 10.1038/s41698-025-01106-1. PMID: 41203797
Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles
Ruano JL, Bejarano L, Serrano R, Álvarez-Díaz R, Flores JM, López AC, Blasco MA. Aging (Albany NY). 2025 Sep 17;17(9):2410-2429. doi: 10.18632/aging.206320. Epub 2025 Sep 17. PMID: 40982211
The role of the CXCL12/CXCR4 axis in the immunotherapy of non-small cell lung cancer
Rogado J, Pozo F, Troule K, Pacheco M, Adrados M, Sánchez-Torres JM, Al-Shahrour F, Aspa J, Alfranca A, Romero-Laorden N, Colomer R. Clin Transl Oncol. 2025 Jul;27(7):2970-2981. doi: 10.1007/s12094-024-03828-3. Epub 2024 Dec 21. PMID: 39708256
Telomere Dysfunction in Renal Tubular Epithelial Cells Leads to Kidney Fibrosis
Saraswati S, Martínez P, Serrano R, Mejías D, Graña-Castro O, Álvarez-Díaz R, Flores JM, Blasco MA.
J Am Soc Nephrol. 2025 Jul 8. doi: 10.1681/ASN.0000000771. Epub ahead of print.
PMID: 40627828
Molecular profiling unveils genetic complexity and identifies potential new driver mechanisms in head and neck paragangliomas
Mellid S, Caleiras E, Martinez-Montes A, Arenas A, Jiménez S, Monteagudo M, Letón R, Radu R, Álvarez-Díaz R, Arroba E, Díaz-Talavera A, Martínez-Puente N, Alvarez-Escolá C, Pineda M, Balbin M, Al-Shahrour F, Rodriguez-Antona C, Montero-Conde C, Leandro-García L, Cascon A.
Genes & Diseases. 2025 Jun 01;101705. doi: 10.1016/j.gendis.2025.101705.
Link
Artificial intelligence in neuro-oncology: methodological bases, practical applications and ethical and regulatory issues
Delgado-López PD, Cárdenas Montes M, Troya García J, Ocaña-Tienda B, Cepeda S, Martínez Martínez R, Corrales-García EM.
Clin Transl Oncol. 2025 May 22. doi: 10.1007/s12094-025-03948-4. Epub ahead of print.
PMID: 40402414
How ready are endocrine scientists to share retrospective clinical data for research: a perspective from the European Network for the Study of Adrenal Tumors.
Sojat AS, Rance B, Neuraz A, Fassnacht M, Beuschlein F, Robledo M, Luconi M, Vassiliadi D, Stell A, Igaz P, Dugic B, Marina LV, Burgun A, Kastelan D, Assie G; European Network for the Study of Adrenal Tumors (ENSAT)/COST Action Harmonisation (CA 20122) consortium (Al-Shahrour F, co‑author and member of the consortium). Eur J Endocrinol. 2025 Mar 27;192(4):491-509. doi: 10.1093/ejendo/lvaf005. PMID: 40289285
Macrophages harness hepatocyte glutamate to boost liver regeneration
Rigual MDM, Angulo-Aguado M, Zagorac S, Álvarez-Díaz R, Benítez-Mondéjar M, Yi F, Martínez-Garay C, Santos-de-Frutos K, Kim E, Campos-Olivas R, Djouder N.
Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08778-6. Epub ahead of print.
PMID: 40140584
The state of the human coding gene catalogues
Maquedano M, Cerdán-Vélez D, Tress ML. Database (Oxford). 2025 Jan 18;2025:baaf045. doi: 10.1093/database/baaf045. PMID: 40996716
